Symbol
Name
ID

Col4a5
collagen, type IV, alpha 5
MGI:88456

Phenotype annotations related to renal/urinary system

Darker colors indicate more annotations

Human Phenotypes

Hematuria

Microscopic hematuria

Proteinuria

Renal glomerular foam cells

Glomerular basement membrane lamellation

Thickened glomerular basement membrane

Thin glomerular basement membrane

Thickening of glomerular capillary wall

Mesangial hypercellularity

Glomerular C3 deposition

IgA deposition in the glomerulus

Focal segmental glomerulosclerosis

Renal tubular atrophy

Tubulointerstitial fibrosis

Nephritis

Nephrotic syndrome

Renal insufficiency

Stage 5 chronic kidney disease

Disease(s) Associated with COL4A5

Alport syndrome

X-linked Alport syndrome

Mouse Phenotypes

abnormal glomerular capillary morphology

dilated glomerular capillary

increased mesangial cell number

increased urine protein level

albuminuria

hematuria

tubulointerstitial nephritis

abnormal kidney morphology

abnormal renal glomerular capsule morphology

podocyte foot process effacement

abnormal renal glomerulus basement membrane morphology

increased renal glomerulus basement membrane thickness

abnormal renal glomerulus morphology

expanded mesangial matrix

glomerulosclerosis

renal glomerular synechia

renal interstitial fibrosis

renal tubule atrophy

abnormal renal tubule morphology

dilated renal tubule

pale kidney

Availability

Mouse Genotype

Col4a5^{tm1b(EUCOMM)Wtsi}/Col4a5^{tm1b(EUCOMM)Wtsi}

Col4a5^tm1Yseg/Col4a5⁺

Col4a5^em1Keha/Y

Col4a5^{tm1b(EUCOMM)Wtsi}/Y

Col4a5^tm1Yseg/Y

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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